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It is recommended that Celexa be administered as a single oral dose of 20 mg daily. Take Celexa exactly as it was prescribed for you. Celexa is an antidepressant drug used to treat depression. You are taking. Celexa is an astonishing antidepressant medication that affects neurotransmitters, the chemical transmitters within the brain. Take Celexa together with a monoamine oxidase inhibitor. As a single oral dose of 20 mg daily.